Focal Epithelial Hyperplasia - Heck's Disease
FEH was noticed in eskimos in Greenland as early as 1894, but 1965 Archard, Heck and Stanley described the lesions among indians, using the term "Fokal Epithelial Hyperplasia", as the soft lesions did not clinically resemble papillomas. However, later on HPV type 13 and type 32 was described in the lesions. 
However, later on HPV type 13 and type 32 was described in the lesions. The lesions are rarely seen here in scandinavians but they are quite common in countries lining the Mediteranian, in South- and Middle America, as well as in Greenland and in Canada.
HPV is without symptoms, it is not premalignant and it may disappear years after first notice. The leasons do not appear to be highly contagious. The interesting thing is that here is a leasion with a clinical and a histological appearance, specific for HPV types 13 and 32.
The HPV type can be demon-strated in different ways - DNA in sity hybridization (left) or for example by PCR with consensus-primers, followed by RFLP (right).
